They have thick roots on Pandora, being one of the first settlers to arrive on Pandora. They operate a pub which also acts as their base of operations just outside the town of Overlook. However they have always been at odds with another well-known clan, the Hodunks.
The Zafords as a clan appear in Borderlands 2 at odds with the Hodunks. For this, they are willing to hire any mercenary to attack the other clan. This leads to the Clan War quests. While the entire clan as a whole appears only in Borderlands 2, a member appears in Borderlands. Lucky Zaford who is Mick Zaford's son runs a bar called Lucky's Last Chance Watering Hole in the Dahl Headlands is a part of the clan.
A Zaford clan member appears in the intro for Tales from the Borderlands unearthing a loot box, he is then assassinated by a generic bandit wielding the Skullmasher.