Tyreen The Destroyer is the final boss of Borderlands 3.
Tyreen The Destroyer presents itself as the boss during the mission Divine Retribution, who engages the Vault Hunters to finally kill them. With The Destroyer threatening the universe, the Vault Hunters slay it, ending her once and for all.
- Main article: Divine Retribution
- Tyreen the Destroyer has an increased chance to drop the legendary King's Call pistol, Queen's Call pistol, and the Bitch submachine gun.
- If Tyreen's eye is shot with the Face-puncher shotgun (a non-melee source of melee damage) during her phase on all fours, she will take damage and become immune as if the character attacked her with normal melee, but she will remain on all fours until a certain time has passed, retaining her immunity until then as well.