“Look out, everybody, things are about to get awesome!”
After speaking to Tannis who notices an odd signal from a far-off planet known as Minos Prime, she tasks the Vault Hunter(s) to go investigate the signal. As Sanctuary III arrives to the space outside the planet, Tannis and the Vault Hunter(s) see that it is if the planet exploded.
After arriving, Tannis deduces the planet, which appears to have exploded, has done so from the inside. From here, the Vault Hunter(s) enter onto the surface of Minos Prime, fight through several waves of native fauna, only to find crystals. Tannis has the Vault Hunter(s) charge the crystals and proceed further in. As they do, the Vault Hunter(s) hear cryptic messages spoken by an unknown voice only known as "Martyr".
Upon defeating a guardian named Anathema the Relentless, Tannis notes it is unusual for this kind of behavior with guardians, and that this could only be possible by the work of a higher-rank guardian who is intelligent and has upset the order of the guardians themselves. Tannis is ultimately proven right as the Vault Hunter(s) encounter Scourge the Invincible Martyr, who immediately enters combat with the Vault Hunter(s) upon arrival to his chambers. Despite Scourge's power, however, the Vault Hunter(s) overpower Scourge, destroying him and apparently wiping all of the guardians with Scourge off of Minos Prime and the galaxy itself. Tannis congratulates the Vault Hunter(s), and the quest for the Takedown is completed.