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Spiderant knights generally spawn along with other lesser spiderants. They are unique in that they have incredibly tough frontal armor which greatly reduces all bullet damage. Their abdomens have large plates of armor on them as well, making it harder to score critical hits and finish them off. Spiderant Knights also perform short radius AoE damage against targets which does moderate to medium damage. They are not as dangerous as some of the other variants of spiderant, and can be considered as a means to distract Vault Hunters from more dangerous but fragile spiderants nearby.
- In True Vault Hunter Mode, they are renamed Centurion Spiderant. In Ultimate Vault Hunter Mode, they are renamed Gallant Spiderant.
- Main article: Spiderant#General_Strategy