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Rex Loader is only encountered during the mission 5UP4-3G0-TP, as the villian in a fictional scenario being acted out by 5UP4-3G0-TP. He arrives in an airship with Minion reinforcements and does battle with 5UP4-3G0-TP. The Vault Hunters never actually interact with Rex Loader directly -- all of his actions and dialogue are triggered by the mission, and he is not seen after the mission is complete.
- Main article: 5UP4-3G0-TP (mission)