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The Omega Mantakore is armored and will be initially weak to corrosive weapons until the armor depletes. Because of its large size, weapons with area-of-effect damage such as the Cutsman or the Flakker are very effective. The Omega Mantakore mostly attacks from an out-of-bounds area using ranged attacks that deal corrosive damage, so weapons that have a short range or slow projectile speed may be less effective.
- As the Omega Mantakore will not respawn once killed, any unique drops obtained from it can only be acquired once per playthrough unless a backed-up save file is loaded.
- The Mantakore's name is a combination of Manta and Korax, the two creatures that combine to form it.
- It is also a reference to the mythological Manticore, a being the Mantakore is visually similar to.