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Natural Selection Annex from the Creature Slaughter Dome DLC is a Circle of Slaughter map. It is located to the right of the vending machines after entering the first structure in the Wildlife Exploitation Preserve with the collapsed telescope (eastern end of the map).
DLC was released on December 12, 2012 as paid DLC and as a part of the Borderlands 2: GOTY Edition release on October 8, 2013. Entering without it is still possible if a pre-order or paid owner's game is joined. If the mission is obtained but not completed this way, access is granted independently until mission completion.
The arena itself is a mixture of all animal habitats in the Wildlife Exploitation Preserve, featuring slag ponds and stalker goo as well as varkid hives and skag holes.
- Creatures in the arena will focus on the Vault Hunters and not attack each other unless no other targets are available.
- A Vault Hunter can become locked in the spawning area. If the character is alone and dies after going to the meeting point but prior activating the switch (e.g. suiciding with a rocket launcher) they will respawn in the area for eliminated characters but the round won't count as failed. The remedy is to save and exit.
- The DLC could originally only be accessed by purchasing a pre-order copy of Borderlands 2 from certain retailers that came with a special key for the DLC.