NPC

Human

• Baron Flynt - Claims to be the leader of Pandora's bandits. Headquartered on a large digging machine in the Salt Flats. Former employee of Patricia Tannis.
• Chuck Durden - Owner of the circle of slaughter located in the Rust Commons West.
• Commandant Steele - Leader of the Crimson Lance.
• Crazy Earl - Shut-in who lives in Crazy Earl's Scrapyard, off of Rust Commons West, and has a pet Skag, which he lovingly calls "Skrappy."
• Dr. Zed - The town doctor in Fyrestone. Later moves to New Haven along with the player.
• Erik Franks -
• Ernest Whitting - A renowned hunter located just inside the entrance of the Dahl Headlands from the Arid Badlands.
• Helena Pierce - Settlement administrator based out of New Haven. She has an artificial left arm.
• Hudson Johns - "Custodian" of the Middle of Nowhere Bounty Board.
• Jaynis Kobb - Brother of Taylor Kobb. Leader of Jaynistown in Rust Commons East. Exiles his brother from the settlement for unknown reasons.
• Lucky Zaford - Runs Lucky's Last Chance Watering Hole. Allegedly had relations with Scooter's mother that ended badly for both parties.
• Marcus Kincaid - Narrator, bus driver, and merchant extraordinaire.
• Patricia Tannis - Former scientific adviser for the Dahl Corporation. Obsessed with finding the Vault.
• Scooter - Auto-mechanic who maintains the Catch-a-Ride System on Pandora.
• Shep Sanders - Friend of Dr. Zed whom needs your help with a few missions.
• Taylor Kobb - Brother of Jaynis Kobb. Exiled from Jaynistown for unknown reasons.
• T.K Baha - A blind widower who lives just outside Fyrestone, near Skag Gully. Also has an artificial leg.
• Rade Zayben - Owner of the Circle of Death located in the Arid Badlands.
• Dr. Ned Dr. Zed's not-made-up brother

Robot

• Claptrap - A small robot that introduces you to the game and will help you along with side missions throughout your stay on Pandora. (There is more than one Claptrap unit, however: see: Claptrap Rescue Missions)

Other

• Guardian Angel - Mysterious benefactor to the player. Can "see" everything on Pandora through the ECHOnet.