SPOILERS!Below is information that may adversely affect the reader's enjoyment of the game.
As an infant, Maya was identified as a Siren and given to the Order of the Impending Storm, the ruling order of monks on her homeworld of Athenas. She trained her Siren powers in secret until she reached adulthood, when the monks revealed her to the public as their goddess and savior. Irritated by the Order's short leash, she longed for adventure and expressed interest in traveling to Pandora to learn more about her Siren lineage. She eventually realized that the Order was using her as a threat to extort money and obedience from the people of Athenas. After Phaselocking and executing her handler Brother Sophis, she headed to Pandora to finally satisfy her curiosity about Sirens.
Maya already knew of the Vault and the presence of Eridium before arriving on Pandora. After Handsome Jack learned of Maya through Hyperion surveillance footage of Athenas, it presumably didn't take much effort to get the Siren on the train at the beginning of the game.
Upon disembarking the train and standing on the train platform, Maya is surprised when she spots a bandit named Krieg staring back at her; when he tries calling out to her, Maya believes him to have malevolent intent and begins shooting at him. As this goes on, a swarm of rats begin approaching Maya, who is unaware of the danger. Maya is only saved due to Krieg screaming out a warning and killing a rat with his buzzsaw. She proceeds to help kill most of the rats and as she leaves, Krieg calls out to her once more; this time, Maya forms a slight smile in appreciation for him saving her life.
After the events of Borderlands 2, Maya decided to travel back to Athenas and serve as the planet's protector. Before she left Pandora to return back home to Athenas, Maya is surprised to encounter Krieg once again. Sensing that he was upset and trying to express his disappointment about her leaving him behind on Pandora, Maya comforts Krieg and promises to come back and see him someday.
While on Athenas, Maya is informed about a thief named Ava who tried stealing one of her books in the monastery. Instead of throwing her off a cliff for the crime, Maya took her in as an apprentice. After stopping Maliwan's invasion of Athenas in search for the vault key, Maya and Ava join the Crimson Raiders in the fight against the Calypsos.
At the vault on Promethea, Ava confronts Maya on being left on Sanctuary III while The Rampager was fought. When Tyreen Calypso later takes Ava hostage, Maya puts Troy Calypso in a chokehold to try bartering Ava's life for his; however, none of the people present were aware that Troy could leech off other Sirens (as he had always relied on Tyreen), and thus Maya was promptly disintegrated after Troy leeched her powers.
Action Skill: Phaselock. Base Cooldown is 13 seconds, base Duration is 5 seconds.
Maya's skill gives her the ability to suspend foes in another dimension. This can lock an opponent in a stasis, and can be upgraded to provide various damaging effects. This skill is useful for crowd control in both co-op and single player mode. Repeatedly Phaselocking the same enemy results in diminishing returns.
Maya has three Skill trees:
- Main article: Class Mod (Borderlands 2)#Maya
- Main article: Maya/ECHO Recorders
- Main article: Maya/Quotes
- Maya's equipped class mod is represented by a book attached to her left hip.
- Maya is wanted for the crime of being a siren; the bounty on her head is $720,000,000,000.
- An ECHO recording appears in Maya's inventory at the start of the game about her training with a group of mysterious "Brothers" and explains why she left her planet to come to Pandora.
- Maya's backstory ECHO recordings are located in the Wildlife Exploitation Preserve. The recordings override earlier promotional material regarding her age, giving her at least 27 years instead of 25.
- One of Maya's body skins, "Slice of Fried Gold", is a reference to the movie Shaun of the Dead. 
- Maya's "So it goes..." quote comes from Kurt Vonnegut's novel Slaughterhouse-Five in which the phrase is used after the death of any character.
- Maya was the first Vault Hunter to meet Krieg. She originally mistook him for a common bandit. Krieg's inner voice then persuaded Krieg to save Maya's life from an approaching rat horde. 
- According to Mad Moxxi, Maya gives her a "ladyboner".