Katagawa Ball has heavy armor and an immense amount of shield (two-thirds of its health are made up of shield). To defeat it, use corrosive damage on the armor, then switch to shock damage to deplete its shield. Shooting the plating on the sides of the ball disables the rockets and makes the fight easier. Because Katagawa Ball moves quickly, it is best to keep moving and not let it out of sight.
- During the fight, Katagawa Ball will state "Remember the Zanara". This is a reference to the 1898 sinking of the USS Maine which precipitated the Spanish-American War, under the slogan "Remember the Maine! To hell with Spain!