The Handsome Dragon first appears at the Unassuming Docks, when it appears as the first boss. When first encountered, it cannot be damaged. The Dragon then spews a fireball that can easily down a character, before it is removed from the game to be replaced with a different boss known as Mister Boney Pants Guy.
- In its first appearance, the Handsome Dragon is added to Tiny Tina's game by Tina herself before Lilith argues against putting such a powerful boss in the start of the game.
- The Handsome Dragon commonly drops Eridium, several blue and purple rarity items (including spell grenades), and numerous stacks of money.
- The Handsome Sorcerer refers to the Handsome Dragon as Smokey.
- If enough time passes during the boss fight with the Handsome Dragon, Tina will bring the White Knight into the battle to assist the character.
- The Handsome Dragon is Tina's allegory for The Warrior.