Arachnes are specialized units of spider enemies that are larger than most other units. They are encountered only in the Tiny Tina's Assault on Dragon Keep DLC. Arachnes are half human, half spider hybrids that wield a a bow and arrow.
Arachnes primarily attack from a distance using bows that fire arrows in a long arching trajectory. The damage output for each arrow is quite high, although this is offset by a slow rate for fire, and a slow projectile speed that makes them relatively easy to evade at long range. The arrows have a significant impact and any character sprinting towards an Arachne will be momentarily halted when hit by one. If an attacker gets close, Arachnes will resort to using a melee attack that deals corrosive damage. They are vulnerable to incendiary damage and are resistant to corrosive damage. Their abdomen is a critical hit point.
- In Greek mythology, Arachne was a great mortal weaver who boasted her skill was greater than the goddess Athena. After a contest, Athena was enraged by Arachne's skill and turned her into a spider.