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The Adaptive Virus's most unique feature is that after taking elemental damage, it will morph into a version resistant to that elemental type. For instance, it might become a Corrosive-Adapted Virus. The effect does wear off over time, and ends in Nova blast of the element the virus was adapted to. If using elemental weapons, this necessitates weapon swapping in order to maintain combat effectiveness. Using barrels or Volatile Bits can be an effective way to force Viruses to adopt desired adaptations.
Adaptive Viruses attack with either melee or ranged attacks, the ranged attacks lobbing projectiles at the Vault Hunters.
- In True Vault Hunter Mode, they are renamed Chameleon Virus, and in Ultimate Vault Hunter Mode, they are renamed Chimera Virus.