Forum:Armor vs Weapon Damage (Multipliers)

I don't see a lot in the wiki about how enemy armor works against PC weapon damage.

Really, I suppose my question is "is there any difference (all other things being equal) between a weapon with a damage of 100 and a weapon with a damage of 50x2 or 25x4? I would assume all three weapons would function similarly against unarmored/unshielded NPCs, but was wondering if armor/shields protected against any of those better than the others? :Kevin