User blog comment:Neeeeeeenja7/What exactly are the differences in playthrough 1, 2 , and 2.5?/@comment-64.13.23.92-20100527213420

Not much else, to be honest. I enjoyed playthrough 2 and 2.5 more than playthrough 1, because of the difficulty. Playthrough 2.5 doesn't have any missions, it's more of a....difficulty reward for beating playthrough 2. If you skip the sidequests in PL 2, you can do them in PL 2.5 instead, with harder enemies. I've found that it's more fun to start a new game with a different character, after you're invincible from beating everything.